Dr. Slump(1981)

Original title: Dr.スランプ アラレちゃん

Senbei Norimaki, known by his nickname Dr. Slump, a genius yet under-respected inventor and roboticist, creates an android by the name of Arale, and poses her as his little sister. What starts as an experiment in robotics turns into an adventure every day for the residents of Penguin Village, a wacky rural community with several colorful characters interacting with Arale and her creator.