Maria(2001)

Original title: マリア

Four sisters are all involved with the medical field. Sora inherits a medical clinic in Shinjuku from her father, while Umi is a doctor researching gene therapy. Riku's husband owns a large hospital, and Mimi is a trainee doctor dreaming of becoming famous. The four sisters are shocked to meet an unknown half-sister, Hiyo, from Hokkaido.